PBRM1-BD2-IN-5

• CAT Number: I042610
• CAS Number: 2819989-61-0
• Molecular Formula: C15H13ClN2O
• Molecular Weight: 272.73
• Purity: ≥95%
• Synonyms: 5-chloro-2-(3-methylphenyl)-2,3-dihydro-1H-quinazolin-4-one
• InChI: InChI=1S/C15H13ClN2O/c1-9-4-2-5-10(8-9)14-17-12-7-3-6-11(16)13(12)15(19)18-14/h2-8,14,17H,1H3,(H,18,19)
• InChIKey: OBDBCXGMLSMARG-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC=C1)C2NC3=C(C(=CC=C3)Cl)C(=O)N2

PBRM1-BD2-IN-5（Cat No.:I042610）is a selective inhibitor targeting bromodomain 2 (BD2) of the PBRM1 protein, a subunit of the SWI/SNF chromatin remodeling complex. PBRM1 plays a critical role in regulating gene expression by interacting with acetylated histones and modulating chromatin structure. Inhibiting BD2 with PBRM1-BD2-IN-5 aims to disrupt this interaction, potentially influencing tumor suppressor gene activation and altering gene expression patterns. This compound is being investigated for its therapeutic potential in cancer, especially in tumors with mutations in the PBRM1 gene, offering a novel approach to targeting chromatin remodeling pathways in oncology.