For research use only. Not for therapeutic Use.
PBRM1-BD2-IN-8（Cat No.:I042609）is a selective inhibitor targeting the bromodomain 2 (BD2) of the PBRM1 protein, which is a component of the SWI/SNF chromatin remodeling complex. PBRM1 plays a critical role in regulating gene expression by influencing chromatin structure. By inhibiting the BD2 domain, PBRM1-BD2-IN-8 aims to modulate the interaction between PBRM1 and acetylated histones, potentially affecting tumor suppressor gene expression. This compound is being investigated for its therapeutic potential in cancer, particularly in tumors with mutations or altered expression of PBRM1, to enhance targeted cancer therapies and gene regulation.
| CAS Number | 2819989-75-6 |
| Synonyms | 5-bromo-2-(3-methylphenyl)-2,3-dihydro-1H-quinazolin-4-one |
| Molecular Formula | C15H13BrN2O |
| Purity | ≥95% |
| IUPAC Name | 5-bromo-2-(3-methylphenyl)-2,3-dihydro-1H-quinazolin-4-one |
| InChI | InChI=1S/C15H13BrN2O/c1-9-4-2-5-10(8-9)14-17-12-7-3-6-11(16)13(12)15(19)18-14/h2-8,14,17H,1H3,(H,18,19) |
| InChIKey | PXWIXTCIXZCREB-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CC=C1)C2NC3=C(C(=CC=C3)Br)C(=O)N2 |
