PC786

• CAT Number: I034283
• CAS Number: 1902114-15-1
• Molecular Formula: C41H38FN5O4S
• Molecular Weight: 715.84
• Purity: 98%
• Synonyms: PC-786; PC 786; PC786
• Target: RSV
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Store at -20°C
• IUPAC Name: N-(2-fluoro-6-methylphenyl)-6-[4-[[5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)pyridine-3-carbonyl]amino]benzoyl]-4,5-dihydrothieno[3,2-d][1]benzazepine-2-carboxamide
• InChI: InChI=1S/C41H38FN5O4S/c1-25-20-31(37(43-22-25)46-23-41(24-46)15-18-51-19-16-41)38(48)44-29-12-10-27(11-13-29)40(50)47-17-14-28-21-34(52-36(28)30-7-3-4-9-33(30)47)39(49)45-35-26(2)6-5-8-32(35)42/h3-13,20-22H,14-19,23-24H2,1-2H3,(H,44,48)(H,45,49)
• InChIKey: VTCJNYICQADBJD-UHFFFAOYSA-N
• SMILES: CC1=C(C(=CC=C1)F)NC(=O)C2=CC3=C(S2)C4=CC=CC=C4N(CC3)C(=O)C5=CC=C(C=C5)NC(=O)C6=C(N=CC(=C6)C)N7CC8(C7)CCOCC8

PC786（Cat No.:I034283）is a potent, selective inhibitor of the bromodomain and extraterminal (BET) family of proteins, particularly targeting BRD4. By blocking the interaction between BET proteins and acetylated lysine residues on histones, PC786 disrupts transcriptional processes that drive cancer cell growth, making it a promising candidate in cancer therapy, especially for hematologic malignancies. This compound is under investigation for its potential to modulate key signaling pathways involved in cell proliferation and survival. PC786 is expected to complement existing therapies by targeting epigenetic regulation in cancer cells.

Reference

1: Mirabelli C, Jaspers M, Boon M, Jorissen M, Koukni M, Bardiot D, Chaltin P, Marchand A, Neyts J, Jochmans D. Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium. J Antimicrob Chemother. 2018 Mar 27. doi: 10.1093/jac/dky089. [Epub ahead of print] PubMed PMID: 29596680; PubMed Central PMCID: PMC6005027.
2: Brookes DW, Coates M, Allen H, Daly L, Constant S, Huang S, Hows M, Davis A, Cass L, Ayrton J, Knowles I, Strong P, Rapeport G, Ito K. Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium. Br J Pharmacol. 2018 Jun;175(12):2520-2534. doi: 10.1111/bph.14221. Epub 2018 May 2. PubMed PMID: 29579332; PubMed Central PMCID: PMC5980447.
3: Coates M, Brookes D, Kim YI, Allen H, Fordyce EAF, Meals EA, Colley T, Ciana CL, Parra GF, Sherbukhin V, Stockwell JA, Thomas JC, Hunt SF, Anderson-Dring L, Onions ST, Cass L, Murray PJ, Ito K, Strong P, DeVincenzo JP, Rapeport G. Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor. Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00737-17. doi: 10.1128/AAC.00737-17. Print 2017 Sep. PubMed PMID: 28652242; PubMed Central PMCID: PMC5571287.