For research use only. Not for therapeutic Use.
PCI-33380 is an irreversible and selective Bruton’s Tyrosine Kinase (BTK) inhibitor (fluorescent probe).
PCI-33380 bound to Btk could be detected by denaturing gel electrophoresis and fluorescent gel scanning[2].
| Catalog Number | I014554 |
| CAS Number | 1022899-36-0 |
| Molecular Formula | C46H52BF2N11O3 |
| Purity | ≥95% |
| Reference | [1]. Zuo Y, et al. A novel 2,5-diaminopyrimidine-based affinity probe for Bruton’s tyrosine kinase. Sci Rep. 2015 Nov 4;5:16136. [2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80. |
