For research use only. Not for therapeutic Use.
PCSK9-IN-12 is a heteroaryl compound. PCSK9-IN-12 has bind affinity for PCSK9 with a Kd value of ＜200 nM. PCSK9-IN-12 can be used for the research of cholesterol metabolism[1].
PCSK9-IN-12 (compound 458B) has affinity for PCSK9 with a Kd value of ＜200 nM[1].
| Catalog Number | I041987 |
| CAS Number | 2455427-91-3 |
| Synonyms | 1-[6-[[(1S,3S)-3-[[5-(difluoromethoxy)pyrimidin-2-yl]amino]cyclopentyl]amino]pyridin-3-yl]pyridin-2-one |
| Molecular Formula | C20H20F2N6O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H20F2N6O2/c21-19(22)30-16-11-24-20(25-12-16)27-14-5-4-13(9-14)26-17-7-6-15(10-23-17)28-8-2-1-3-18(28)29/h1-3,6-8,10-14,19H,4-5,9H2,(H,23,26)(H,24,25,27)/t13-,14-/m0/s1 |
| InChIKey | NCHUWRLOTSAFFN-KBPBESRZSA-N |
| SMILES | C1CC(CC1NC2=NC=C(C=C2)N3C=CC=CC3=O)NC4=NC=C(C=N4)OC(F)F |
| Reference | [1]. Michael H. Serrano-Wu, et al. Pcsk9 inhibitors and methods of use thereof. Patent. WO2020150474A1. |
