PD 116779

• CAT Number: I008578
• CAS Number: 102674-89-5
• Molecular Formula: C19H14O6
• Molecular Weight: 338.32
• Purity: ≥95%
• Synonyms: PD116,779; PD 116,779; PD-116,779; PD-116779; PD116779; PD 116779;2,3,8-trihydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 2,3,8-trihydroxy-3-methyl-2,4-dihydrobenzo[a]anthracene-1,7,12-trione
• InChI: InChI=1S/C19H14O6/c1-19(25)7-8-5-6-10-14(12(8)17(23)18(19)24)16(22)9-3-2-4-11(20)13(9)15(10)21/h2-6,18,20,24-25H,7H2,1H3
• InChIKey: ZGIMJLWQWQRQNJ-UHFFFAOYSA-N
• SMILES: CC1(CC2=C(C(=O)C1O)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4O)O

PD 116779（Cat No.:I008578）is a selective inhibitor of the enzyme 5-lipoxygenase (5-LO), which plays a central role in the biosynthesis of leukotrienes, inflammatory mediators involved in allergic reactions, asthma, and other inflammatory conditions. By inhibiting 5-LO, PD 116779 helps reduce the production of leukotrienes, thereby alleviating inflammation and related symptoms. It has been studied for its potential in treating conditions such as asthma, allergic rhinitis, and other chronic inflammatory diseases. Preclinical and clinical trials are exploring its safety and efficacy as an anti-inflammatory agent, though further research is necessary for broader therapeutic use.