PD 123319 ditrifluoroacetate

• CAT Number: I001413
• CAS Number: 136676-91-0
• Molecular Formula: C31H32N4O3 • 2CF3COOH
• Molecular Weight: 736.7
• Purity: ≥95%
• Synonyms: (6S)-1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid;2,2,2-trifluoroacetic acid;hydrate
• Target: Angiotensin Receptor
• Solubility: H2O: ≥ 36 mg/mL
• Storage: 2-8°C
• IC50: 34 nM
• IUPAC Name: (6S)-1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C31H32N4O3.2C2HF3O2/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24;2*3-2(4,5)1(6)7/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38);2*(H,6,7)/t28-;;/m0../s1
• InChIKey: GPKQIEZLHVGJQH-ZXVJYWQYSA-N
• SMILES: CC1=C(C=CC(=C1)CN2C=NC3=C2CC(N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

PD 123319（Cat No.:I001413） is a highly effective and specific AT2 angiotensin II receptor antagonist, exhibiting an IC50 value of 34 nM. This compound demonstrates potent inhibition of AT2 receptor activity, indicating its ability to selectively block the binding of angiotensin II to the AT2 receptor. With its remarkable potency, PD 123319 holds significant promise as a valuable tool compound for studying the biological functions and therapeutic potential associated with AT2 receptor modulation.

Reference

[1]. Blankley CJ, et al. Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J Med Chem. 1991 Nov;34(11):3248-60.
[2]. Zhou J, et al. A novel angiotensin receptor subtype in rat mesangium. Coupling to adenylyl cyclase. Hypertension. 1993 Jun;21(6 Pt 2):1035-8.
[3]. Estrup TM, et al. No effect of angiotensin II AT(2)-receptor antagonist PD 123319 on cerebral blood flow autoregulation. J Renin Angiotensin Aldosterone Syst. 2001 Sep;2(3):188-92.
[4]. Brillante DG, et al. Effects of intravenous PD 123319 on haemodynamic and arterial stiffness indices in healthy volunteers. J Renin Angiotensin Aldosterone Syst. 2005 Sep;6(2):102-6.
[5]. Coleman CM, et al. Angiotensin AT1-receptor inhibition exacerbates renal injury resulting from partial unilateral ureteral obstruction in the neonatal rat. Am J Physiol Renal Physiol. 2007 Jul;293(1):F262-8.