PD 135158

• CAT Number: I008598
• CAS Number: 130325-35-8
• Molecular Formula: C35H44N4O6
• Molecular Weight: 616.76
• Purity: ≥95%
• Synonyms: Cam 1028; Cam-1028; Cam1028; PD-135158; PD135158; PD 135158;(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy-N-methylhexan-1-aminium 4-(((1S)-2-((2S)-3-(1H-indol-3-yl)-2-methyl-2-(((((2S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)oxy)carbonyl)amino)propanamido)-1
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• Storage: Store at +4C
• IUPAC Name: 4-[[(1R)-2-[[(2R)-3-(1H-indol-3-yl)-2-methyl-2-[[(1S,2R,4S)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]oxycarbonylamino]propanoyl]amino]-1-phenylethyl]amino]-4-oxobutanoic acid
• InChI: InChI=1S/C35H44N4O6/c1-33(2)24-16-17-34(33,3)28(18-24)45-32(44)39-35(4,19-23-20-36-26-13-9-8-12-25(23)26)31(43)37-21-27(22-10-6-5-7-11-22)38-29(40)14-15-30(41)42/h5-13,20,24,27-28,36H,14-19,21H2,1-4H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t24-,27-,28+,34+,35+/m0/s1
• InChIKey: NNTPEWZUKRSTMM-VVUNRPKCSA-N
• SMILES: C[C@]12CC[C@H](C1(C)C)C[C@H]2OC(=O)N[C@](C)(CC3=CNC4=CC=CC=C43)C(=O)NC[C@@H](C5=CC=CC=C5)NC(=O)CCC(=O)O

PD 135158(CAT: I008598) is a potent and selective endothelin receptor antagonist, primarily utilized in cardiovascular and renal research. It exhibits high affinity for ETA receptors, effectively inhibiting endothelin-1-induced vasoconstriction and mitigating associated pathophysiological processes. This compound is instrumental in exploring therapeutic strategies for conditions such as hypertension, pulmonary arterial hypertension (PAH), and heart failure. With exceptional stability and purity, PD 135158 is ideal for in vitro and in vivo studies, providing reliable results in endothelin signaling pathway investigations. It serves as a valuable tool in advancing cardiovascular and renal therapeutic research.