For research use only. Not for therapeutic Use.
PD 135158 is a Selective cholecystokinin type B (CCKB)/gastrin receptor agonist. In studies, PD- 135158 stimulates lipase release from isolated rat pancreatic acini dose dependently in a biphasic manner, with identical efficacy but lower potency compared to cholecystokinin octapeptide (CCK-8). PD 135158 is classified into Anti-Anxiety Agents, Central Nervous System Agents, Central Nervous System Depressants, Psychotropic Drugs, and Tranquilizing Agents.
| Catalog Number | I008598 |
| CAS Number | 130325-35-8 |
| Synonyms | Cam 1028; Cam-1028; Cam1028; PD-135158; PD135158; PD 135158;(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy-N-methylhexan-1-aminium 4-(((1S)-2-((2S)-3-(1H-indol-3-yl)-2-methyl-2-(((((2S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)oxy)carbonyl)amino)propanamido)-1 |
| Molecular Formula | C35H44N4O6 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| Storage | Store at +4C |
| Reference | </br>1:PD-135158, a CCKB receptor antagonist, microinjected into the nucleus accumbens and the expression of conditioned rewarded behavior. Josselyn SA, Franco VP, Vaccarino FJ.Neurosci Lett. 1996 May 10;209(2):85-8. PMID: 8761988 </br>2:PD 135158, a CCKB/gastrin receptor antagonist, stimulates rat pancreatic enzyme secretion as a CCKA receptor agonist. Höcker M, Hughes J, Fölsch UR, Schmidt WE.Eur J Pharmacol. 1993 Sep 21;242(1):105-8. PMID: 7901038 |
