PD 151746

• CAT Number: I002326
• CAS Number: 179461-52-0
• Molecular Formula: C11H8FNO2S
• Molecular Weight: 237.248
• Purity: ≥95%
• Target: calpain
• Solubility: DMSO: ≥ 37 mg/mL
• Storage: Store at -20°C
• IC50: 0.26 ± 0.03 μM (Ki, for μ-calpain), 5.33 ± 0.77 μM (Ki, for m-calpain) [1]
• IUPAC Name: (Z)-3-(5-fluoro-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid
• InChI: InChI=1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-
• InChIKey: HWMQHECFXSVZGN-KMKOMSMNSA-N
• SMILES: C1=CC2=C(C=C1F)C(=CN2)C=C(C(=O)O)S

PD 151746 (Cat.No:I002326) is a selective antagonist of the angiotensin II type 1 receptor (AT1 receptor). It is used in preclinical research to study the physiological and pathological roles of the renin-angiotensin system. PD 151746 has been investigated for its potential applications in cardiovascular disorders and hypertension. Further research is ongoing to explore its therapeutic potential.

Reference

[1]. Wang KK, et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.
[2]. P?rn-Ares MI, et al. Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells. Biochem J. 2003 Sep 1;374(Pt 2):403-11.