For research use only. Not for therapeutic Use.
PD 153035 hydrochloride(CAT: I001926) represents a breakthrough in the realm of targeted kinase inhibition and cancer research. This compound, also referred to as PD153035 (ZM 252868; AG 1517), stands out as a potent and specific inhibitor of the epidermal growth factor receptor (EGFR). With a remarkable Ki of 5.2 pM and IC50 of 29 pM, PD 153035 hydrochloride demonstrates exceptional selectivity and affinity for EGFR. Notably, its minimal impact on other receptors such as PDGFR, FGFR, CSF-1, InsR, and Src enhances its specificity.
Catalog Number | I001926 |
CAS Number | 153436-54-5 |
Synonyms | N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine |
Molecular Formula | C₁₆H₁₄BrN₃O₂.HCl |
Purity | ≥95% |
Target | Protein Tyrosine Kinase/RTK |
Solubility | 10 mM in DMSO |
Storage | Store at RT |
IC50 | 5.2/29 pM(Ki/IC50) [1] |
InChI | InChI=1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H |
InChIKey | ZJOKWAWPAPMNIM-UHFFFAOYSA-N |
SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl |
Reference | <p style=/line-height:25px/> |