PD 169316

• CAT Number: I001889
• CAS Number: 152121-53-4
• Molecular Formula: C₂₀H₁₃FN₄O₂
• Molecular Weight: 360.34
• Purity: ≥95%
• Synonyms: 4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine
• Target: p38
• Solubility: DMSO 10 mg/mL; Water <1 mg/mL
• Storage: Store at -20C
• IC50: 89 nM
• InChI: InChI=1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
• InChIKey: BGIYKDUASORTBB-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)[N+](=O)[O-]

PD 169316（Cat No.:I001889）is a potent and selective inhibitor of p38 MAPK, specifically targeting the p38α and p38β isoforms. It is widely used in research to study the role of p38 MAPK in inflammation, apoptosis, and stress-related cellular responses. By inhibiting p38 MAPK, PD 169316 reduces the production of pro-inflammatory cytokines, making it valuable for investigating inflammatory diseases such as rheumatoid arthritis, as well as cancer and neurodegenerative disorders. Its selectivity and effectiveness make PD 169316 a key tool for exploring therapeutic strategies targeting the p38 MAPK signaling pathway.

Reference

[1]. Fu Y, et al. The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochem Biophys Res Commun. 2003 Oct 17;310(2):391-7.
[2]. Nath R, et al. Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons. Cell Mol Biol Lett. 2001;6(2):173-84.
[3]. Kozawa O, et al. p38 MAP kinase is involved in the signalling of sphingosine in osteoblasts: sphingosine inhibits prostaglandin F(2alpha)-induced phosphoinositide hydrolysis. Cell Signal. 2000 Jul;12(7):447-50.
[4]. Brooks AC, et al. Endotoxin-induced activation of equine digital vein endothelial cells: role of p38 MAPK. Vet Immunol Immunopathol. 2009 Jun 15;129(3-4):174-80.