For research use only. Not for therapeutic Use.
PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR with an IC50 of 450 pM[1].
| Catalog Number | I008620 |
| CAS Number | 216163-53-0 |
| Synonyms | N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide |
| Molecular Formula | C17H15BrN4O |
| Purity | ≥95% |
| InChI | InChI=1S/C17H15BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h3-10H,2H2,1H3,(H,21,23)(H,19,20,22) |
| InChIKey | WUPUZEMRHDROEO-UHFFFAOYSA-N |
| SMILES | CCC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br |
| Reference | [1]. Fry DW, et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12022-7. |
