For research use only. Not for therapeutic Use.
PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively[1] .
PD 90780 (0.1-100 μM; 2 h) affects 125I-BDNF binds to truncated p75NTR[1].
PD 90780 (100 μM; 2 h) inhibits 125I-NGF cross-linking to p75NTR[1].
PD 90780 (0-300 μM; 2 h) decreases TrkA phosphorylation resulting from NGF binding with a dose of 300 μM[1].
PD 90780 (0.1-100 μM; 2 h) inhibits NGF-p75NTR interaction with IC50 values of 23.1 µM and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively[1].
| Catalog Number | R014128 |
| CAS Number | 77422-99-2 |
| Synonyms | 7-benzamido-4-methyl-9-oxopyrazolo[5,1-b]quinazoline-2-carboxylic acid |
| Molecular Formula | C19H14N4O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H14N4O4/c1-22-15-8-7-12(20-17(24)11-5-3-2-4-6-11)9-13(15)18(25)23-16(22)10-14(21-23)19(26)27/h2-10H,1H3,(H,20,24)(H,26,27) |
| InChIKey | IAZAGXDMMVWYKF-UHFFFAOYSA-N |
| SMILES | CN1C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3)C(=O)N4C1=CC(=N4)C(=O)O |
| Reference | [1]. Colquhoun A , et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J |
