For research use only. Not for therapeutic Use.
PD0332991(Cat No.:I004131), also known as palbociclib, is a highly selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). By inhibiting CDK4/6, PD0332991 prevents the phosphorylation of the retinoblastoma protein (Rb), thereby inhibiting the progression of the cell cycle from the G1 phase to the S phase. This results in cell cycle arrest and suppression of cell proliferation. PD0332991 has shown promising activity in the treatment of hormone receptor-positive, HER2-negative advanced breast cancer, both as monotherapy and in combination with endocrine therapy. It has also shown potential in other types of cancers, including lung cancer and lymphomas. Clinical studies have demonstrated its efficacy and safety profile, leading to its approval for certain indications.
Catalog Number | I004131 |
CAS Number | 571190-30-2 |
Synonyms | 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one; PD-0332991; Palbociclib |
Molecular Formula | C24H29N7O2 |
Purity | ≥95% |
Target | Cyclin-Dependent Kinases |
Solubility | DMSO: 0.2 mg/mL (Need ultrasonic or warming) |
Storage | Store at -20°C |
Overview of Clinical Research | <span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Palbociclib is a cyclin-dependent kinase 4 inhibitor as well as a cyclin-dependent kinase 6 inhibitor, which is marketed to treat breast caner.</span></span></span> |
IUPAC Name | 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one |
InChI | InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) |
InChIKey | AHJRHEGDXFFMBM-UHFFFAOYSA-N |
SMILES | CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C |
Reference | <p> |