For research use only, not for therapeutic use.
PD0407824（Cat No.:I008571）is a potent and selective inhibitor of mitogen-activated protein kinase kinase 1 (MEK1), a key enzyme in the MAPK/ERK signaling pathway. By inhibiting MEK1, it prevents the activation of ERK, which is involved in cell proliferation, survival, and differentiation. PD0407824 has shown promise in cancer research, particularly in targeting tumors with aberrant MAPK signaling, such as melanoma and colorectal cancer. Its ability to disrupt this pathway makes it a valuable compound for exploring targeted cancer therapies, aiming to inhibit tumor growth and progression with high specificity.
| Catalog Number | I008571 |
| CAS Number | 622864-54-4 |
| Synonyms | PD0407824; PD-0407824; PD 0407824; PD407824; PD-407824; PD 407824;9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione |
| Molecular Formula | C20H12N2O3 |
| Purity | ≥95% |
| Target | Chk1 inhibitor |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 9-hydroxy-4-phenyl-6H-pyrrolo[3,4-c]carbazole-1,3-dione |
| InChI | InChI=1S/C20H12N2O3/c23-11-6-7-14-13(8-11)16-15(21-14)9-12(10-4-2-1-3-5-10)17-18(16)20(25)22-19(17)24/h1-9,21,23H,(H,22,24,25) |
| InChIKey | IAUZTOZLTFSMIE-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=CC3=C(C4=C(N3)C=CC(=C4)O)C5=C2C(=O)NC5=O |
| Reference | </br>1: Neurofibromatoses therapeutic agents and screening for same. By Fernandez-Valle, Cristina. From PCT Int. Appl. (2013), WO 2013138463 A1 20130919.</br>2:Methods of treating cancer via modulation of deoxythymidylate kinase (DTYMK) and checkpoint kinase-1 (CHK1). By Wong, Kwok-Kin; Liu, Yan. From PCT Int. Appl. (2013), WO 2013103836 A2 20130711. |
