For research use only. Not for therapeutic Use.
PD1-PDL1-IN 1 TFA (compound 16) is a potent programmed cell death 1 (PD-1) inhibitor. PD1-PDL1-IN 1 TFA is useful as immune modulator[1].
PD-1 (or Programmed Cell Death 1 or PDCD1) is a ~55kD type I membrane glycoprotein and is a receptor of the CD28 superfamily that negatively regulates T cell antigen receptor signalling by interacting with the specific ligands. PD-1 is suggested to play significant role in the maintenance of self-tolerance[1].
| Catalog Number | I041437 |
| Synonyms | (2S,3R)-2-[[(1S)-3-amino-3-oxo-1-(3-piperazin-1-yl-1,2,4-oxadiazol-5-yl)propyl]carbamoylamino]-3-hydroxybutanoic acid;2,2,2-trifluoroacetic acid |
| Molecular Formula | C16H24F3N7O8 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H23N7O6.C2HF3O2/c1-7(22)10(12(24)25)18-14(26)17-8(6-9(15)23)11-19-13(20-27-11)21-4-2-16-3-5-21;3-2(4,5)1(6)7/h7-8,10,16,22H,2-6H2,1H3,(H2,15,23)(H,24,25)(H2,17,18,26);(H,6,7)/t7-,8+,10+;/m1./s1 |
| InChIKey | JHTXTLJOVWXUDK-QVUDESDKSA-N |
| SMILES | CC(C(C(=O)O)NC(=O)NC(CC(=O)N)C1=NC(=NO1)N2CCNCC2)O.C(=O)(C(F)(F)F)O |
| Reference | [1]. Pottayil Govindan Nair Sasikumar , et al. 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators. WO2016142886A2. |
