For research use only. Not for therapeutic Use.
PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with Ki values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective[1].
PD150606 interacts with both calcium-binding domains (μ- and m-calpains) of Calpain[1].
PD150606 attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices[1].
PD 150606 (25 μM; 0-12 hours) reduces Cycloheximide (10 mg/ml) -triggered apoptosis of neutrophils[2].
| Catalog Number | I002330 |
| CAS Number | 179528-45-1 |
| Synonyms | (Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid |
| Molecular Formula | C9H7IO2S |
| Purity | ≥95% |
| InChI | InChI=1S/C9H7IO2S/c10-7-3-1-6(2-4-7)5-8(13)9(11)12/h1-5,13H,(H,11,12)/b8-5- |
| InChIKey | DJCVSFWGKYHMKH-YVMONPNESA-N |
| SMILES | C1=CC(=CC=C1C=C(C(=O)O)S)I |
| Reference | [1]. 1. Wang KK et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92. [2]. 2. Squier MK , et al. Calpain and calpastatin regulate neutrophil apoptosis. J Cell Physiol. 1999 Mar;178(3):311-9. |
