PD173955

• CAT Number: I002889
• CAS Number: 260415-63-2
• Molecular Formula: C21H16Cl2N4OS
• Molecular Weight: 443.35
• Purity: ≥95%
• Synonyms: 6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido[2,3-d]pyrimidin-7-one
• Target: Bcr-Abl
• Solubility: DMSO: ≥ 32 mg/mL
• Storage: Store at -20 ℃
• IC50: 22 nM

PD173955 is a potent and selective inhibitor of the Bcr-Abl tyrosine kinase, an enzyme commonly associated with chronic myelogenous leukemia (CML). This small molecule inhibitor is used in research to study signal transduction pathways and the molecular mechanisms underlying cancer, particularly CML. PD173955 also exhibits activity against Src-family kinases, making it valuable in broader cancer research. By inhibiting these kinases, PD173955 helps in understanding and potentially disrupting the signaling pathways that drive cancer cell proliferation and survival.