For research use only. Not for therapeutic Use.
PDE10-IN-5（Cat No.:I043443）is a selective inhibitor of phosphodiesterase 10A (PDE10A), an enzyme that regulates intracellular levels of cyclic AMP (cAMP) and cyclic GMP (cGMP) by degrading them. PDE10A is predominantly expressed in the brain, where it plays a role in modulating dopaminergic signaling. By inhibiting PDE10A, PDE10-IN-5 enhances the signaling of cAMP and cGMP, which can potentially improve cognitive functions and have therapeutic effects in neurological disorders. Research suggests PDE10-IN-5 may be useful in treating conditions like schizophrenia, Parkinson’s disease, and Huntington’s disease by modulating dopaminergic pathways.
| CAS Number | 898562-99-7 |
| Synonyms | 2-[[4-[4-pyridin-4-yl-2-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline |
| Molecular Formula | C26H19F3N4O |
| Purity | ≥95% |
| IUPAC Name | 2-[[4-[4-pyridin-4-yl-2-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline |
| InChI | InChI=1S/C26H19F3N4O/c27-26(28,29)17-33-25(23(15-31-33)18-11-13-30-14-12-18)20-6-9-22(10-7-20)34-16-21-8-5-19-3-1-2-4-24(19)32-21/h1-15H,16-17H2 |
| InChIKey | KOQAWTNMUMMWMO-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C=CC(=N2)COC3=CC=C(C=C3)C4=C(C=NN4CC(F)(F)F)C5=CC=NC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
