For research use only. Not for therapeutic Use.
(S)-C33 is a potent and selective PDE9A inhibitor with an IC50 value of 11 nM.
KEYWORDS: PDE9A inhibitor C33(S) | supplier | PDE9A inhibitor | (S)-C33 | CAS [2066488-39-7] | cGMP | PDE | Inhibitor | Enzymes | PDE9 | PDE9A
| Catalog Number | I034329 |
| CAS Number | 2066488-39-7 |
| Molecular Formula | C18H20ClN5O |
| Purity | ≥95% |
| IUPAC Name | 6-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-1-cyclopentyl-5H-pyrazolo[3,4-d]pyrimidin-4-one |
| InChI | InChI=1S/C18H20ClN5O/c1-11(12-6-8-13(19)9-7-12)21-18-22-16-15(17(25)23-18)10-20-24(16)14-4-2-3-5-14/h6-11,14H,2-5H2,1H3,(H2,21,22,23,25)/t11-/m0/s1 |
| SMILES | C[C@@H](C1=CC=C(C=C1)Cl)NC2=NC3=C(C=NN3C4CCCC4)C(=O)N2 |
| Reference | M Huang et al. Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol Pharmacol. 2015 Nov;88(5):836-45.
PX Wang et al. C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling. Acta Pharmacol Sin. 2017 Sep;38(9):1257-1268. |
