For research use only. Not for therapeutic Use.
PDEC-NB（Cat No.:I017614） is a disulfide cleavable linker designed for use in antibody-drug conjugates (ADCs). It consists of a disulfide bond that can be selectively cleaved under specific conditions, such as the presence of reducing agents. This linker allows for the controlled release of the attached drug payload from the antibody carrier within the target cell, enhancing the therapeutic efficacy of ADCs. The use of PDEC-NB as a linker in ADCs offers a strategy for targeted drug delivery, enabling the selective delivery of potent cytotoxic agents to tumor cells.
| Catalog Number | I017614 |
| CAS Number | 874302-76-8 |
| Molecular Formula | C₁₄H₁₂N₂O₅S₂ |
| Purity | ≥95% |
| Target | ADC Linker |
| IUPAC Name | (4-nitrophenyl) 2-(pyridin-2-yldisulfanyl)ethyl carbonate |
| InChI | InChI=1S/C14H12N2O5S2/c17-14(21-12-6-4-11(5-7-12)16(18)19)20-9-10-22-23-13-3-1-2-8-15-13/h1-8H,9-10H2 |
| InChIKey | JHDROZPIXZYTMZ-UHFFFAOYSA-N |
| SMILES | C1=CC=NC(=C1)SSCCOC(=O)OC2=CC=C(C=C2)[N+](=O)[O-] |
| Reference | [1]. Chunguang Ren et al. A kind of reduction response type cancer target polypeptide drugs conjugate and its preparation method and application. CN110314237A |
