PDK4-IN-1 hydrochloride

• CAT Number: I016175
• CAS Number: 2310262-11-2
• Molecular Formula: C₂₂H₂₀ClN₃O₂
• Molecular Weight: 393.87
• Purity: ≥95%
• Target: Apoptosis
• IUPAC Name: 1-(1-piperidin-4-ylpyrazol-4-yl)anthracene-9,10-dione;hydrochloride
• InChI: InChI=1S/C22H19N3O2.ClH/c26-21-17-4-1-2-5-18(17)22(27)20-16(6-3-7-19(20)21)14-12-24-25(13-14)15-8-10-23-11-9-15;/h1-7,12-13,15,23H,8-11H2;1H
• InChIKey: ZIMLKZKPNALXKK-UHFFFAOYSA-N
• SMILES: C1CNCCC1N2C=C(C=N2)C3=C4C(=CC=C3)C(=O)C5=CC=CC=C5C4=O.Cl

PDK4-IN-1 hydrochloride (Cat No.:I016175) is a hydrochloride salt form of PDK4-IN-1, a selective inhibitor of pyruvate dehydrogenase kinase 4 (PDK4). PDK4 is an enzyme that regulates the activity of pyruvate dehydrogenase complex (PDC), a key enzyme involved in glucose metabolism. By inhibiting PDK4, PDK4-IN-1 promotes the activity of PDC, leading to increased glucose oxidation and energy production. PDK4-IN-1 has shown potential as a therapeutic agent for metabolic disorders such as diabetes and obesity. Further studies are ongoing to explore its pharmacological applications and therapeutic benefits.

Reference

[1]. Lee D, et al. Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases. J Med Chem. 2019 Jan 24;62(2):575-588.