For research use only. Not for therapeutic Use.
PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an Ki of 1.2±0.4 nM.
PDM2 (Compound 4b) exhibits a Ki of 1.2±0.4 nM for AhR and no affinity for estrogen receptor (ER), confirming that replacement of hydroxyl with chloride abolished binding on ER and increased dramatically the affinity for AhR[1].
| Catalog Number | I011432 |
| CAS Number | 688348-25-6 |
| Synonyms | 1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene |
| Molecular Formula | C14H9Cl3 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H9Cl3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9H/b2-1+ |
| InChIKey | JMYNPQVCVQVODQ-OWOJBTEDSA-N |
| SMILES | C1=CC(=CC=C1C=CC2=CC(=CC(=C2)Cl)Cl)Cl |
| Reference | [1]. de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. |
