For research use only. Not for therapeutic Use.
PDTC (Cat.No:I003830), also known as pyrrolidine dithiocarbamate, is a chemical compound that acts as an antioxidant and metal chelator. It has been studied for its potential in modulating immune responses, inhibiting inflammation, and suppressing the activity of certain enzymes involved in cancer progression. PDTC holds promise as a therapeutic agent for various diseases.
| Catalog Number | I003830 |
| CAS Number | 5108-96-3 |
| Synonyms | ammonium pyrrolidine-1-carbodithioate |
| Molecular Formula | C₅H₉NS₂.NH₃ |
| Purity | ≥95% |
| Target | NF-κB |
| Solubility | DMSO: ≥ 42 mg/mL |
| Storage | Store at RT |
| InChI | InChI=1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3 |
| InChIKey | MDDIUTVUBYEEEM-UHFFFAOYSA-N |
| SMILES | C1CCN(C1)C(=S)[S-].[NH4+] |
| Reference | </br>1:Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and CYP2E1 content of rats with immunological liver injury. Qin JD, Cao ZH, Li XF, Kang XL, Xue Y, Li YL, Zhang D, Liu XY, Xue YZ.Pharm Biol. 2014 Nov;52(11):1460-6. doi: 10.3109/13880209.2014.898075. Epub 2014 Jun 25. PMID: 24963944 </br>2:Ammonium pyrrolidine dithiocarbamate anchored Symphoricarpus albus biomass for lead(II) removal: batch and column biosorption study. Akar ST, Arslan D, Alp T.J Hazard Mater. 2012 Aug 15;227-228:107-17. doi: 10.1016/j.jhazmat.2012.05.020. Epub 2012 May 14. PMID: 22673058 </br>3:Ammonium pyrrolidine dithiocarbamate and RS 102895 attenuate opioid withdrawal in vivo and in vitro. Rehni AK, Singh N.Psychopharmacology (Berl). 2012 Mar;220(2):427-38. doi: 10.1007/s00213-011-2489-8. Epub 2011 Sep 20. PMID: 21931991 </br>4:Determination of tin by resin-suspension electrothermal atomic absorption spectrometry after enrichment as the complex with ammonium pyrrolidinedithiocarbamate. Taruki M, Wakui T, Nukatsuka I, Ohzeki K.Anal Sci. 2007 Dec;23(12):1435-8. PMID: 18071232 Free Article</br>5:Speciation analysis of tellurium by solid-phase extraction in the presence of ammonium pyrrolidine dithiocarbamate and inductively coupled plasma mass spectrometry. Yu C, Cai Q, Guo ZX, Yang Z, Khoo SB.Anal Bioanal Chem. 2003 May;376(2):236-42. Epub 2003 Apr 11. PMID: 12690421 </br>6:Collection of trace heavy metals complexed with ammonium pyrrolidinedithiocarbamate on surfactant-coated alumina sorbents. Hiraide M, Iwasawa J, Kawaguchi H.Talanta. 1997 Feb;44(2):231-7. PMID: 18966739 </br>7:Graphite-furnace atomic absorption spectrometric determination of lead, cadmium, cobalt and nickel in infant formulas and evaporated milks after nitric-perchloric acid digestion and coprecipitation with ammonium pyrrolidine dithiocarbamate. Dabeka RW.Sci Total Environ. 1989 Dec 15;89(3):271-7. PMID: 2559479 </br>8:Determination of chromium(III) and chromium(IV) by ammonium pyrrolidinecarbodithioate-methyl isobutyl ketone furnace atomic absorption spectrometry. Subramanian KS.Anal Chem. 1988 Jan 1;60(1):11-5. No abstract available. PMID: 3344968 </br>9:Total arsenic in foods after sequential wet digestion, dry ashing, coprecipitation with ammonium pyrrolidine dithiocarbamate, and graphite-furnace atomic absorption spectrometry. Dabeka RW, Lacroix GM.J Assoc Off Anal Chem. 1987 Sep-Oct;70(5):866-70. PMID: 3680127 </br>10:Neutron activation analysis of normal and cadmium injected rat liver using ammonium pyrrolidinedithiocarbamate extraction. Shinogi M, Fukuda K, Nakazawa M, Mori I.Radioisotopes. 1980 Aug;29(8):368-72. PMID: 7208991 |
