Peceleganan acetate

• CAT Number: I041393
• Molecular Formula: C140H230N36O36
• Molecular Weight: 2993.55
• Purity: ≥95%

Peceleganan (PL-5) acetate is an artificial antimicrobial cecropin A (1-10) × melittin B (3-18) hybrid (10+16)-peptide analogue. Peceleganan acetate inhibits wound infection[1].
Peceleganan (24 h) acetate shows antibacterial activity with MICs of 2, 2, 4, 4, 4 and 8 μM against E. coli ATCC 25922, S. pneumonia ATCC 49619, K. pneumonia ATCC 700603, S. aureus ATCC 25923, S. epidermidis ATCC 12228 and P. aeruginosa ATCC 27853, respectively[2].
Peceleganan (0.4 and 0.75 mg/mL for 100 μL; transdermal; twice daily for 3 days) acetate inhibits Staphylococcus aureus in the mouse infection model[2].

Reference

[1]. WHO Drug Information. International Nonproprietary Names for Pharmaceutical.

[2]. Feng Q, et al. Functional synergy of α-helical antimicrobial peptides and traditional antibiotics against Gram-negative and Gram-positive bacteria in vitro and in vivo. Eur J Clin Microbiol Infect Dis. 2015 Jan;34(1):197-204.
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