For research use only. Not for therapeutic Use.
Peficitinib(CAT: I005617) is a potent and selective Janus kinase (JAK) inhibitor widely utilized in immunology and inflammation research. By targeting JAK1, JAK2, JAK3, and TYK2, it disrupts cytokine-mediated signaling pathways, making it a valuable tool for studying autoimmune and inflammatory diseases. Researchers leverage Peficitinib to explore therapeutic approaches for conditions such as rheumatoid arthritis, psoriasis, and other immune-related disorders. With its high specificity and efficacy, Peficitinib is essential for preclinical studies aiming to advance drug discovery and develop innovative treatments for chronic inflammatory diseases.
| CAS Number | 944118-01-8 |
| Synonyms | ASP015K |
| Molecular Formula | C18H22N4O2 |
| Purity | ≥95% |
| Target | Stem Cell/Wnt |
| Solubility | DMSO: ≥ 60 mg/mL |
| Storage | Store at -20°C |
| IC50 | 3.9/5.0/0.71 nM (for JAK1/2/3) , 4.8 nM (for Tyk2) |
| IUPAC Name | 4-[[(1R,3S)-5-hydroxy-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide |
| InChI | InChI=1S/C18H22N4O2/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10/h1-2,8-11,14,24H,3-7H2,(H2,19,23)(H2,20,21,22)/t9-,10-,11+,14+,18- |
| InChIKey | DREIJXJRTLTGJC-ZKVNVPQCSA-N |
| SMILES | NC(C1=CN=C2C(C=CN2)=C1N[C@@H]3[C@H](C4)C[C@@]5(O)C[C@@H]3C[C@@H]4C5)=O |
