For research use only. Not for therapeutic Use.
PEG3-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016093 |
| CAS Number | 282551-10-4 |
| Synonyms | 2-[2-[2-(methylamino)ethoxy]ethoxy]ethanol |
| Molecular Formula | C7H17NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C7H17NO3/c1-8-2-4-10-6-7-11-5-3-9/h8-9H,2-7H2,1H3 |
| InChIKey | OJIGMRILIXVTEA-UHFFFAOYSA-N |
| SMILES | CNCCOCCOCCO |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
