PEG3-O-CH2COOH

• CAT Number: I018635
• CAS Number: 51951-05-4
• Molecular Formula: C₈H₁₆O₆
• Molecular Weight: 208.21
• Purity: ≥95%
• Target: PROTAC Linkers

PEG3-O-CH2COOH (CAT: I018635) is a PEG-based molecule commonly used as a linker in the synthesis of SNIPERs (Specifically Targeted Protein Degradation Inducers). SNIPERs are bifunctional molecules that harness the cellular ubiquitin-proteasome system to induce targeted protein degradation. In the context of SNIPERs, PEG3-O-CH2COOH serves as a linker that connects the targeting ligand for the protein of interest to a ligand for an E3 ubiquitin ligase, leading to the ubiquitination and subsequent degradation of the targeted protein.

Reference

[1]. Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570.