PEG4-aminooxy-MMAF

• CAT Number: I018014
• CAS Number: 1415246-35-3
• Molecular Formula: C₄₇H₈₂N₆O₁₂
• Molecular Weight: 923.19
• Purity: ≥95%
• IUPAC Name: (2S)-2-[[(2R,3R)-3-[(2S)-1-[(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-[2-[2-[2-(2-aminooxyethoxy)ethoxy]ethoxy]ethyl-methylamino]-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl]-3-methoxy-2-methylpropanoyl]amino]-3-phenylpropanoic acid
• InChI: InChI=1S/C47H82N6O12/c1-12-33(6)42(52(9)46(57)40(31(2)3)50-45(56)41(32(4)5)51(8)21-22-62-23-24-63-25-26-64-27-28-65-48)38(60-10)30-39(54)53-20-16-19-37(53)43(61-11)34(7)44(55)49-36(47(58)59)29-35-17-14-13-15-18-35/h13-15,17-18,31-34,36-38,40-43H,12,16,19-30,48H2,1-11H3,(H,49,55)(H,50,56)(H,58,59)/t33-,34+,36-,37-,38+,40-,41-,42-,43+/m0/s1
• InChIKey: OJYZGXVPCDZLCK-KVEFUIBJSA-N
• SMILES: CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)CCOCCOCCOCCON

PEG4-aminooxy-MMAF（Cat No.:I018014）is a versatile linker used in antibody-drug conjugates (ADCs), combining polyethylene glycol (PEG) with the cytotoxic agent MMAF (monomethyl auristatin F). The aminooxy group facilitates stable attachment to antibodies, enhancing the delivery of MMAF directly to cancer cells while minimizing systemic toxicity. This compound leverages the benefits of PEG for improved solubility and pharmacokinetics, making it ideal for targeted therapies. By effectively utilizing MMAF’s potent microtubule-disrupting properties, PEG4-aminooxy-MMAF represents a promising approach in the development of precision oncology treatments.

Reference

[1]. Samantha Congreve, et al. Antibody drug conjugates (ADC). Teknisk- naturvetenskaplig fakultet