PEG4-SPDP

• CAT Number: I017615
• CAS Number: 1305053-43-3
• Molecular Formula: C₂₀H₂₈N₂O₈S₂
• Molecular Weight: 488.57
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(pyridin-2-yldisulfanyl)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C20H28N2O8S2/c23-18-4-5-19(24)22(18)30-20(25)6-8-26-9-10-27-11-12-28-13-14-29-15-16-31-32-17-3-1-2-7-21-17/h1-3,7H,4-6,8-16H2
• InChIKey: AZXJOPLHLVNPKQ-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCSSC2=CC=CC=N2

PEG4-SPDP (Cat No.:I017615) is a versatile cleavable linker that can be used to synthesize antibody-drug conjugates (ADCs). As an ADC linker, PEG4-SPDP plays a crucial role in connecting the antibody and the drug payload, allowing for targeted drug delivery to cancer cells. The cleavable nature of PEG4-SPDP enables the release of the drug once the ADC is internalized by the cancer cells, improving drug efficacy and reducing off-target effects. Its use is widespread in drug discovery and development for the treatment of cancer and other diseases.

Reference

[1]. Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54(10):3606-23.