For research use only. Not for therapeutic Use.
PEG5-(CH2CO2H)2（Cat No.:I014556） is a polyethylene glycol (PEG) derivative that possesses two terminal carboxylic acid groups. These carboxylic acids can be selectively reacted with primary amine groups using activators like EDC (ethyl-3-(3-dimethyl aminopropyl)carbodiimide) or DCC (dicyclohexylcarbodiimide) to form stable amide bonds. This PEG linker is particularly valuable in the development of antibody-drug conjugates (ADCs), where it enables the conjugation of drugs or payloads to antibodies via controlled and stable linkages. PEG linkers provide increased solubility, improved pharmacokinetics, and reduced immunogenicity, making them essential tools in ADC design and drug delivery strategies.
| Catalog Number | I014556 |
| CAS Number | 77855-75-5 |
| Synonyms | PEG5-(CH2CO2H)2;3,6,9,12,15-pentaoxaheptadecanedioic acid |
| Molecular Formula | C12H22O9 |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| IUPAC Name | 2-[2-[2-[2-[2-(carboxymethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid |
| InChI | InChI=1S/C12H22O9/c13-11(14)9-20-7-5-18-3-1-17-2-4-19-6-8-21-10-12(15)16/h1-10H2,(H,13,14)(H,15,16) |
| InChIKey | WIVPWKOWHCVJKT-UHFFFAOYSA-N |
| SMILES | C(COCCOCC(=O)O)OCCOCCOCC(=O)O |
| Reference | </br>1: Bonache MA, Alaimo A, Malo C, Millet O, Villarroel A, González-Muñiz R. Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding. Org Biomol Chem. 2014 Nov 28;12(44):8877-87. doi: 10.1039/c4ob01338g. PubMed PMID: 25264745.</br>2: Aroua S, Schweizer WB, Yamakoshi Y. C60 pyrrolidine bis-carboxylic acid derivative as a versatile precursor for biocompatible fullerenes. Org Lett. 2014 Mar 21;16(6):1688-91. doi: 10.1021/ol500363r. Epub 2014 Mar 7. PubMed PMID: 24606113.</br>3: Kakkar D, Tiwari AK, Chuttani K, Khanna A, Datta A, Singh H, Mishra AK. Design, synthesis, and antimycobacterial property of PEG-bis(INH) conjugates. Chem Biol Drug Des. 2012 Aug;80(2):245-53. doi: 10.1111/j.1747-0285.2012.01394.x. Epub 2012 May 30. PubMed PMID: 22515497.</br></br> |
