PEG5-Tos

• CAT Number: I017205
• CAS Number: 155130-15-7
• Molecular Formula: C₁₇H₂₈O₈S
• Molecular Weight: 392.46
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
• InChI: InChI=1S/C17H28O8S/c1-16-2-4-17(5-3-16)26(19,20)25-15-14-24-13-12-23-11-10-22-9-8-21-7-6-18/h2-5,18H,6-15H2,1H3
• InChIKey: NSODVVYOWINKAG-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCOCCO

PEG5-Tos（Cat No.:I017205） is a PEG-based molecule that acts as a proteolysis targeting chimera (PROTAC) linker. It is commonly used in the synthesis of PROTACs, which are designed to target specific proteins for degradation through the ubiquitin-proteasome system. PEG5-Tos is a five-unit polyethylene glycol (PEG) molecule with a tosylate functional group, allowing for conjugation to the ligand for the target protein and the ligand for the E3 ubiquitin ligase.

Reference

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.