For research use only. Not for therapeutic Use.
PEG6-(CH2CO2H)2 (CAT: I014557) is a PEG-based molecule with two carboxylic acid functional groups attached to a polyethylene glycol (PEG) chain of six ethylene glycol units. This compound can be used as a linker in various chemical and biochemical applications, including the synthesis of drug conjugates, bioconjugation, and the modification of biomolecules. The carboxylic acid groups can participate in reactions with amine or hydroxyl groups, enabling the conjugation of molecules or biomolecules through peptide bonds or ester linkages.
| Catalog Number | I014557 |
| CAS Number | 77855-76-6 |
| Synonyms | PEG6-(CH2CO2H)2;3,6,9,12,15,18-hexaoxaicosanedioic acid |
| Molecular Formula | C14H26O10 |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C14H26O10/c15-13(16)11-23-9-7-21-5-3-19-1-2-20-4-6-22-8-10-24-12-14(17)18/h1-12H2,(H,15,16)(H,17,18) |
| InChIKey | DCQRSABUSOYSIY-UHFFFAOYSA-N |
| SMILES | OC(COCCOCCOCCOCCOCCOCC(O)=O)=O |
| Reference | </br>1: Bonache MA, Alaimo A, Malo C, Millet O, Villarroel A, González-Muñiz R. Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding. Org Biomol Chem. 2014 Nov 28;12(44):8877-87. doi: 10.1039/c4ob01338g. PubMed PMID: 25264745.</br>2: Aroua S, Schweizer WB, Yamakoshi Y. C60 pyrrolidine bis-carboxylic acid derivative as a versatile precursor for biocompatible fullerenes. Org Lett. 2014 Mar 21;16(6):1688-91. doi: 10.1021/ol500363r. Epub 2014 Mar 7. PubMed PMID: 24606113.</br>3: Kakkar D, Tiwari AK, Chuttani K, Khanna A, Datta A, Singh H, Mishra AK. Design, synthesis, and antimycobacterial property of PEG-bis(INH) conjugates. Chem Biol Drug Des. 2012 Aug;80(2):245-53. doi: 10.1111/j.1747-0285.2012.01394.x. Epub 2012 May 30. PubMed PMID: 22515497.</br></br> |
