Pelacarsen sodium

• CAT Number: I040079
• CAS Number: 2172851-58-8
• Molecular Formula: C296H419N71Na20O163P20S13
• Molecular Weight: 9076.00
• Purity: ≥95%

Pelacarsen Sodium (Cat No.: I040079) is an antisense oligonucleotide (ASO) inhibitor targeting apolipoprotein(a) [LPA] mRNA, designed to reduce lipoprotein(a) [Lp(a)] levels in cardiovascular disease research. By selectively binding to LPA mRNA, it prevents apo(a) synthesis, lowering Lp(a)-associated cardiovascular risks. Its sodium salt form enhances stability and bioavailability for in vivo and clinical applications. Pelacarsen is a promising therapeutic candidate for atherosclerosis, thrombosis, and lipid metabolism disorders, supporting drug development and precision medicine in cardiovascular disease management.

Reference

[1]. Yeang C, et al. Effect of Pelacarsen on Lipoprotein(a) Cholesterol and Corrected Low-Density Lipoprotein Cholesterol. J Am Coll Cardiol. 2022 Mar 22;79(11):1035-1046.
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[2]. Yu RZ, Graham MJ, Post N, et al. Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice. Mol Ther Nucleic Acids. 2016;5(5):e317.
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[3]. Yu RZ, Gunawan R, Post N, et al. Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys. Nucleic Acid Ther. 2016;26(6):372-380.
[Content Brief]