Pelitrexol

For research use only. Not for therapeutic Use.

  • CAT Number: I008630
  • CAS Number: 446022-33-9
  • Molecular Formula: C20H25N5O6S
  • Molecular Weight: 463.51
  • Purity: ≥95%
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Pelitrexol(Cat No.:I008630)is a folate antagonist primarily used in the treatment of various cancers and autoimmune diseases. It acts by inhibiting dihydrofolate reductase, an enzyme critical for the synthesis of nucleotides, thereby disrupting DNA replication and cell proliferation. Pelitrexol has shown efficacy in treating conditions such as leukemia and lymphoma, as well as in managing rheumatoid arthritis. Its mechanism of action allows for selective targeting of rapidly dividing cells, making it a valuable agent in chemotherapy. Ongoing research aims to better understand its full therapeutic potential and optimize its use in clinical settings.


Catalog Number I008630
CAS Number 446022-33-9
Synonyms

AG 2037; Pelitrexol.;(S)-2-(5-(2-((S)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl)ethyl)-4-methylthiophene-2-carboxamido)pentanedioic acid

Molecular Formula C20H25N5O6S
Purity ≥95%
Solubility Soluble in DMSO, not in water
Storage 0 - 4 °C for short term, or -20 °C for long term
IUPAC Name (2S)-2-[[5-[2-[(6S)-2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl]ethyl]-4-methylthiophene-2-carbonyl]amino]pentanedioic acid
InChI InChI=1S/C20H25N5O6S/c1-9-6-14(18(29)23-12(19(30)31)3-5-15(26)27)32-13(9)4-2-10-7-11-16(22-8-10)24-20(21)25-17(11)28/h6,10,12H,2-5,7-8H2,1H3,(H,23,29)(H,26,27)(H,30,31)(H4,21,22,24,25,28)/t10-,12-/m0/s1
InChIKey QXOPTIPQEVJERB-JQWIXIFHSA-N
SMILES CC1=C(SC(=C1)C(=O)N[C@@H](CCC(=O)O)C(=O)O)CC[C@H]2CC3=C(NC2)N=C(NC3=O)N

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