Pelrinone free base

• CAT Number: I034363
• CAS Number: 94386-65-9
• Molecular Formula: C12H11N5O
• Molecular Weight: 241.25
• Purity: 98%
• Synonyms: Pelrinone Free Base; Pelrinona; Pelrinonum
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 5-Pyrimidinecarbonitrile, 1,4-dihydro-2-methyl-4-oxo-6-((3-pyridinylmethyl)amino)-
• InChI: InChI=1S/C12H11N5O/c1-8-16-11(10(5-13)12(18)17-8)15-7-9-3-2-4-14-6-9/h2-4,6H,7H2,1H3,(H2,15,16,17,18)
• InChIKey: NZXHFDXOCVIYLO-UHFFFAOYSA-N
• SMILES: N#CC1=C(NCC2=CC=CN=C2)NC(C)=NC1=O

Pelrinone Free Base (Cat.No:I034363), a cardiotonic drug, is a phosphodiesterase III inhibitor that was studied in clinical trials phase II for the treatment of patients with heart failure.

Reference

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2: Hajdu J, Adams G, Lee HK. Preformulation study of pelrinone hydrochloride. J Pharm Sci. 1988 Nov;77(11):921-5. doi: 10.1002/jps.2600771104. PMID: 3225750.
3: Patelunas DM, Carmint WJ, Willis JZ, Colatsky TJ, Fenichel RL. Comparative antithrombotic activities of the phosphodiesterase inhibitors pelrinone (AY-26,768), AY-31,390 and milrinone. Thromb Res. 1991 Jun 1;62(5):389-400. doi: 10.1016/0049-3848(91)90012-l. PMID: 1896959.
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6: Kitzen JM, McCallum JD, Pirozzi CT, Colatsky TJ. Potentiation of phosphodiesterase inhibitor antithrombotic activity with alpha-2 adrenergic blockade. Life Sci. 1991;48(7):PL31-5. doi: 10.1016/0024-3205(91)90548-p. PMID: 1671293.
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