Pemetrexed disodium heptahydrate(Cat No.:R015465)is a chemotherapy agent used primarily in the treatment of non-small cell lung cancer and malignant pleural mesothelioma. As a multi-targeted antifolate, it inhibits several enzymes involved in folate metabolism, including thymidylate synthase, leading to disrupted DNA synthesis and cancer cell proliferation. The disodium heptahydrate formulation enhances solubility and bioavailability, facilitating its use in clinical settings. Pemetrexed is often administered in combination with other drugs to improve therapeutic outcomes.
Catalog Number | R015465 |
CAS Number | 357166-29-1 |
Synonyms | N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium Salt Heptahydrate |
Molecular Formula | C20H33N5Na2O13 |
Purity | ≥95% |
Storage | -20°C |
IUPAC Name | disodium;(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate;heptahydrate |
InChI | InChI=1S/C20H21N5O6.2Na.7H2O/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;;;;;;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;7*1H2/q;2*+1;;;;;;;/p-2/t13-;;;;;;;;;/m0........./s1 |
InChIKey | QJVSMHJWAOSBMD-MYXYZBIASA-L |
SMILES | C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.O.O.[Na+].[Na+] |
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