For research use only. Not for therapeutic Use.
(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1]. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action[2].
(+)-penbutolol on the [Ca2+]i-increase induced by LPC is concentration-dependent[1].
(+)-penbutolol inhibits the rounding of cells dose dependently (8±4%, 56±4% and 66±2% at the concentrations of 10-6 M, 5×10-6 M and 10-5 M, respectively)[2].
| Catalog Number | I019582 |
| CAS Number | 38363-41-6 |
| Synonyms | (2R)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol |
| Molecular Formula | C18H29NO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H29NO2/c1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14/h6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3/t15-/m1/s1 |
| InChIKey | KQXKVJAGOJTNJS-OAHLLOKOSA-N |
| SMILES | CC(C)(C)NCC(COC1=CC=CC=C1C2CCCC2)O |
| Reference | [1]. Chen M, et al. Effects of beta-adrenoceptor antagonists on Ca(2+)-overload induced by lysophosphatidylcholine in rat isolated cardiomyocytes. Br J Pharmacol. 1996 Jun;118(4):865-70. [2]. Hashizume H, et al. Effects of antiischemic drugs on veratridine-induced hypercontracture in rat cardiac myocytes. Eur J Pharmacol. 1994 Dec 12;271(1):1-8. |
