For research use only. Not for therapeutic Use.
Penbutolol sulfate（Cat No.:I003413）is a non-selective beta-blocker used primarily to treat hypertension (high blood pressure) and angina (chest pain). It works by blocking beta-adrenergic receptors in the heart and blood vessels, reducing heart rate and the force of contraction, thereby lowering blood pressure and relieving symptoms of angina. Penbutolol also has mild intrinsic sympathomimetic activity, meaning it can partially stimulate beta-receptors while blocking them, which may help reduce bradycardia (slow heart rate). It is typically prescribed when other antihypertensive medications are ineffective or not well tolerated. Common side effects may include dizziness, fatigue, and bradycardia.
| Catalog Number | I003413 |
| CAS Number | 38363-32-5 |
| Molecular Formula | C36H60N2O8S |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | 10 mM in H2O |
| Storage | -20°C |
| IUPAC Name | (2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol;sulfuric acid |
| InChI | InChI=1S/2C18H29NO2.H2O4S/c2*1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14;1-5(2,3)4/h2*6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3;(H2,1,2,3,4)/t2*15-;/m00./s1 |
| InChIKey | FEDSNBHHWZEYTP-ZFQYHYQMSA-N |
| SMILES | CC(C)(C)NC[C@@H](COC1=CC=CC=C1C2CCCC2)O.CC(C)(C)NC[C@@H](COC1=CC=CC=C1C2CCCC2)O.OS(=O)(=O)O |
| Reference | </br>1:Influence of sonophoresis and chemical penetration enhancers on percutaneous transport of penbutolol sulfate. Ita KB, Popova IE.Pharm Dev Technol. 2016 Dec;21(8):990-995. Epub 2015 Sep 18. PMID: 26383739 </br>2:In vitro transdermal iontophoretic delivery of penbutolol sulfate. Ita KB, Banga AK.Drug Deliv. 2009 Jan;16(1):11-4. doi: 10.1080/10717540802396976. PMID: 19555303 |
