For research use only. Not for therapeutic Use.
Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1].
| Catalog Number | I034383 |
| CAS Number | 151937-76-7 |
| Synonyms | 2-(1-azabicyclo[2.2.2]octan-3-yloxy)-1-cyclopentyl-1-phenylethanol;hydrochloride |
| Molecular Formula | C20H30ClNO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H29NO2.ClH/c22-20(18-8-4-5-9-18,17-6-2-1-3-7-17)15-23-19-14-21-12-10-16(19)11-13-21;/h1-3,6-7,16,18-19,22H,4-5,8-15H2;1H |
| InChIKey | DDTVVMRZNVIVQM-UHFFFAOYSA-N |
| SMILES | C1CCC(C1)C(COC2CN3CCC2CC3)(C4=CC=CC=C4)O.Cl |
| Reference | [1]. Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885. |
