For research use only. Not for therapeutic Use.
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8[1][2].
| Catalog Number | R000419 |
| CAS Number | 90-65-3 |
| Synonyms | (2Z)-3-methoxy-5-methyl-4-oxohexa-2,5-dienoic acid |
| Molecular Formula | C8H10O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C8H10O4/c1-5(2)8(11)6(12-3)4-7(9)10/h4H,1H2,2-3H3,(H,9,10)/b6-4- |
| InChIKey | VOUGEZYPVGAPBB-XQRVVYSFSA-N |
| SMILES | CC(=C)C(=O)C(=CC(=O)O)OC |
| Reference | [1]. Sorenson WG, et al. Toxicity of penicillic acid for rat alveolar macrophages in vitro. Environ Res. 1986 Dec;41(2):505-13. [2]. Bando M, et al. The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex. J Biol Chem. 2003 Feb 21;278(8):5786-93. |
