For research use only. Not for therapeutic Use.
Penicillin G Potassium（Cat No.:I000528）is a broad-spectrum antibiotic used to treat various bacterial infections, including pneumonia, meningitis, and sepsis. As a potassium salt of penicillin G, it is typically administered intravenously or intramuscularly for rapid therapeutic effects. This antibiotic works by inhibiting bacterial cell wall synthesis, leading to cell death. It is effective against a wide range of Gram-positive and some Gram-negative bacteria. Due to its high potency, Penicillin G Potassium is often used in hospital settings for severe or life-threatening infections.
| Catalog Number | I000528 |
| CAS Number | 113-98-4 |
| Molecular Formula | C16H17KN2O4S |
| Purity | ≥95% |
| Target | Antibiotic |
| Solubility | H2O: ≥ 48 mg/mL |
| Storage | 3 years -20C powder |
| IUPAC Name | potassium;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| InChI | InChI=1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1 |
| InChIKey | IYNDLOXRXUOGIU-LQDWTQKMSA-M |
| SMILES | CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.[K+] |
| Reference | </br>1:Efficient cascade synthesis of ampicillin from penicillin G potassium salt using wild and mutant penicillin G acylase from Alcaligenes faecalis. Deng S, Ma X, Su E, Wei D.J Biotechnol. 2016 Feb 10;219:142-8. doi: 10.1016/j.jbiotec.2015.12.034. Epub 2015 Dec 28. PMID: 26732414 </br>2:Direct chemiluminescence determination of penicillin G potassium and a chemometrical optimization approach. Sorouraddin MH, Iranifam M, Naseri A, Fadakar-Sardroud M, Gharari-Alibabalou H.Luminescence. 2011 Nov-Dec;26(6):622-8. doi: 10.1002/bio.1285. Epub 2011 Apr 4. PMID: 21465632 </br>3:Error in route of administration of penicillin G potassium. Goerlich A.J Am Vet Med Assoc. 2010 Apr 1;236(7):730; author reply 730. No abstract available. PMID: 20397309 </br>4:Evaluation of penicillin G potassium troches in the treatment of minor recurrent aphthous ulceration in a Chinese cohort: a randomized, double-blinded, placebo and no-treatment-controlled, multicenter clinical trial. Zhou Y, Chen Q, Meng W, Jiang L, Wang Z, Liu J, Lin M, Zhou H, Chen X, Zhao M, Zeng X.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Apr;109(4):561-6. doi: 10.1016/j.tripleo.2009.11.006. Epub 2010 Feb 26. PMID: 20188604 </br>5:The role of penicillin G potassium in managing Clostridium perfringens in broiler chickens. Gadbois P, Brennan JJ, Bruce L, Wilson JB, Aramini JJ.Avian Dis. 2008 Sep;52(3):407-11. PMID: 18939627 </br>6:Electrical conductances of dilute aqueous solutions of sodium penicillin G, potassium penicillin G, and potassium penicillin V in the 278.15-313.15 K temperature range. Bester-Rogac M, Boncina M, Apelblat Y, Apelblat A.J Phys Chem B. 2007 Oct 18;111(41):11957-67. Epub 2007 Sep 22. PMID: 17887789 </br>7:Flow-injection-chemiluminescence method for the determination of penicillin G potassium. Cao W, Yang JH, Sun CX, Zhang ZJ, Gao QF.Luminescence. 2005 Jul-Oct;20(4-5):238-42. PMID: 16134206 </br>8:The efficacy and safety of 50 mg penicillin G potassium troches for recurrent aphthous ulcers. Kerr AR, Drexel CA, Spielman AI.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Dec;96(6):685-94. PMID: 14676759 </br>9:Evaluation of the effects of penicillin G potassium and potassium chloride on the motility of the large intestine in horses. Roussel AJ, Hooper RN, Cohen ND, Bye AD, Hicks RJ, Schulze JL.Am J Vet Res. 2003 Nov;64(11):1360-3. PMID: 14620770 </br>10:Pharmacokinetics of penicillin G procaine versus penicillin G potassium and procaine hydrochloride in horses. Uboh CE, Soma LR, Luo Y, McNamara E, Fennell MA, May L, Teleis DC, Rudy JA, Watson AO.Am J Vet Res. 2000 Jul;61(7):811-5. PMID: 10895905 |
