Pentagamavunon-1

For research use only. Not for therapeutic Use.

  • CAT Number: I015190
  • CAS Number: 27060-70-4
  • Molecular Formula: C₂₃H₂₄O₃
  • Molecular Weight: 348.43
  • Purity: ≥95%
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Pentagamavunon-1 (Cat No.:I015190) is an orally active analog of Curcumin, a natural compound found in turmeric. PGV-1 triggers apoptotic signaling through various mechanisms, including the inhibition of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). Additionally, PGV-1 inhibits the activation of nuclear factor-kappa B (NF-κB), a transcription factor involved in inflammatory and immune responses.


Catalog Number I015190
CAS Number 27060-70-4
Molecular Formula C₂₃H₂₄O₃
Purity ≥95%
Target Immunology/Inflammation
Storage Store at -20°C
IUPAC Name (2E,5E)-2,5-bis[(4-hydroxy-3,5-dimethylphenyl)methylidene]cyclopentan-1-one
InChI InChI=1S/C23H24O3/c1-13-7-17(8-14(2)21(13)24)11-19-5-6-20(23(19)26)12-18-9-15(3)22(25)16(4)10-18/h7-12,24-25H,5-6H2,1-4H3/b19-11+,20-12+
InChIKey OHSKJRMWVIVJCP-AYKLPDECSA-N
SMILES CC1=CC(=CC(=C1O)C)C=C2CCC(=CC3=CC(=C(C(=C3)C)O)C)C2=O
Reference

[1]. Edy Meiyanto, et al. Curcumin Analog Pentagamavunon-1 (PGV-1) Sensitizes Widr Cells to 5-Fluorouracil Through Inhibition of NF-κB Activation. Asian Pac J Cancer Prev. 2018 Jan 27;19(1):49-56.<br>[2]. Beni Lestari, et al. Pentagamavunon-1 (PGV-1) Inhibits ROS Metabolic Enzymes and Suppresses Tumor Cell Growth by Inducing M Phase (Prometaphase) Arrest and Cell Senescence. Sci Rep . 2019 Oct 16;9(1):14867.

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