Pentamidine dihydrochloride

• CAT Number: I003785
• CAS Number: 50357-45-4
• Molecular Formula: C19H26Cl2N4O2
• Molecular Weight: 413.34
• Purity: ≥95%
• Synonyms: [amino-[4-[5-[4-[amino(azaniumylidene)methyl]phenoxy]pentoxy]phenyl]methylidene]azanium;dichloride
• Target: Antibiotic
• Solubility: DMSO 110 mg/mL; Water 110 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide;dihydrochloride
• InChI: InChI=1S/C19H24N4O2.2ClH/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23;;/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);2*1H
• InChIKey: HWURPQUPKQFGJI-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N.Cl.Cl

Pentamidine dihydrochloride (Cat No.:I003785) is an antimicrobial agent used to treat various infections. It exhibits broad-spectrum activity against several microorganisms, including bacteria, fungi, and protozoa. Pentamidine dihydrochloride is commonly used in the treatment of Pneumocystis jirovecii pneumonia (PCP), a severe opportunistic infection often seen in immunocompromised individuals. It works by interfering with the synthesis of nucleic acids and proteins in the microorganisms, thereby inhibiting their growth and replication.

Reference

[1]. Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400.

[2]. Pathak, M.K., et al., Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther, 2002. 1(14): p. 1255-64.