Pentamidine

• CAT Number: I000081
• CAS Number: 100-33-4
• Molecular Formula: C19H24N4O2
• Molecular Weight: 340.40
• Purity: ≥95%
• Synonyms: 4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
• Target: Metabolic Enzyme/Protease
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
• InChIKey: XDRYMKDFEDOLFX-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N

Pentamidine（Cat No.:I000081）is an antiprotozoal and antifungal medication widely used to treat Pneumocystis jirovecii pneumonia (PCP), African trypanosomiasis, and leishmaniasis. It works by binding to parasite DNA, interfering with replication and protein synthesis, ultimately causing parasite death. Administered via injection or inhalation, pentamidine is particularly effective for immunocompromised individuals, such as those with HIV/AIDS. Its broad-spectrum activity makes it a critical tool in managing opportunistic infections. However, its use requires monitoring due to potential side effects, including renal toxicity and hypoglycemia, ensuring safety and efficacy in clinical practice.

Reference

[1]. Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400.

[2]. Pathak, M.K., et al., Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther, 2002. 1(14): p. 1255-64.