Pentamidine

• CAT Number: I000081
• CAS Number: 100-33-4
• Molecular Formula: C19H24N4O2
• Molecular Weight: 340.4
• Purity: ≥95%
• Synonyms: 4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
• Target: Antibiotic
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
• InChIKey: XDRYMKDFEDOLFX-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N

Pentamidine (Cat No.:I000081) is an antimicrobial agent that interferes with DNA biosynthesis. Pentamidine inhibits the parasite Leishmania infantum with IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatase (PTPases) and regenerative liver phosphatase (PRL) inhibitor. Pentamidine can be used in the research of trypanosomiasis gambiae, antimony-resistant leishmaniasis and Pneumocystis carinii pneumonia.

Reference

[1]. Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400.

[2]. Pathak, M.K., et al., Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther, 2002. 1(14): p. 1255-64.