Pentamidine Isethionate

For research use only. Not for therapeutic Use.

  • CAT Number: A000242
  • CAS Number: 140-64-7
  • Molecular Formula: C23H36N4O10S2
  • Molecular Weight: 592.68
  • Purity: ≥95%
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Pentamidine Isethionate(CAT: A000242) is an aromatic amidine derivative. It is commonly used as an antimicrobial agent or an antiparasitic agent, and in recent years has also been studied as an antitumor agent. This product is used for medical research and development and other scientific purposes.


Catalog Number A000242
CAS Number 140-64-7
Synonyms

140-64-7; Pentamidine isethionate salt; 4,4/’-(Pentane-1,5-diylbis(oxy))dibenzimidamide bis(2-hydroxyethanesulfonate); Pentamidine diisethionate; Pentacarinat

Molecular Formula C23H36N4O10S2
Purity ≥95%
Target Antibiotic
Solubility >22.6mg/mL in DMSO
Storage Store at -20°C
InChI 1S/C19H24N4O2.2C2H6O4S/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23;2*3-1-2-7(4,5)6/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);2*3H,1-2H2,(H,4,5,6)
InChIKey YBVNFKZSMZGRAD-UHFFFAOYSA-N
SMILES C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N.C(CS(=O)(=O)O)O.C(CS(=O)(=O)O)O
Reference

1: Mans DR, Kent AD, Hu RV, Lai A Fat EJ, Schoone GJ, Adams ER, Rood EJ, Alba S,
Sabajo LO, Lai A Fat RF, de Vries HJ, Schallig HD. Monitoring the response of
patients with cutaneous leishmaniasis to treatment with pentamidine isethionate
by quantitative real-time PCR, and identification of Leishmania parasites not
responding to therapy. Clin Exp Dermatol. 2016 Aug;41(6):610-5. doi:
10.1111/ced.12786. Epub 2015 Dec 9. PubMed PMID: 26648589.

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2: Hu RV, Straetemans M, Kent AD, Sabajo LO, de Vries HJ, Fat RF. Randomized
single-blinded non-inferiority trial of 7 mg/kg pentamidine isethionate versus 4
mg/kg pentamidine isethionate for cutaneous leishmaniaisis in Suriname. PLoS Negl
Trop Dis. 2015 Mar 20;9(3):e0003592. doi: 10.1371/journal.pntd.0003592.
eCollection 2015 Mar. PubMed PMID: 25793773; PubMed Central PMCID: PMC4368628.
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3: Orgel E, Rushing T. Efficacy and tolerability of intravenous pentamidine
isethionate for Pneumocystis jiroveci prophylaxis in a pediatric oncology
population. Pediatr Infect Dis J. 2014 Mar;33(3):319-21. doi:
10.1097/INF.0000000000000044. PubMed PMID: 24030353.
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4: Sundaramurthi P, Burcusa MR, Suryanarayanan R. Physical characterization of
pentamidine isethionate during freeze-drying-relevance to development of stable
lyophilized product. J Pharm Sci. 2012 May;101(5):1732-43. doi:
10.1002/jps.23055. Epub 2012 Jan 23. PubMed PMID: 22271285.
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5: Siddiqui R, Syed A, Tomas S, Prieto-Garcia J, Khan NA. Effect of free versus
liposomal-complexed pentamidine isethionate on biological characteristics of
Acanthamoeba castellanii in vitro. J Med Microbiol. 2009 Mar;58(Pt 3):327-30.
doi: 10.1099/jmm.0.006494-0. PubMed PMID: 19208882.
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6: Plaza DF, Marino A, Delgado G. Characterizing the effect of pentamidine
isethionate on the immune system using mouse splenocytes as an experimental
model. J Immunotoxicol. 2007 Oct;4(4):279-85. doi: 10.1080/15476910701680087.
PubMed PMID: 18958738.

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7: Akpa PO, Ezeokonkwo RC, Eze CA, Anene BM. Comparative efficacy assessment of
pentamidine isethionate and diminazene aceturate in the chemotherapy of
Trypanosoma brucei brucei infection in dogs. Vet Parasitol. 2008 Feb
14;151(2-4):139-49. Epub 2007 Nov 19. PubMed PMID: 18155842.
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8: Roussel M, Nacher M, Frémont G, Rotureau B, Clyti E, Sainte-Marie D, Carme B,
Pradinaud R, Couppié P. Comparison between one and two injections of pentamidine
isethionate, at 7 mg/kg in each injection, in the treatment of cutaneous
leishmaniasis in French Guiana. Ann Trop Med Parasitol. 2006 Jun;100(4):307-14.
PubMed PMID: 16762111.
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9: Jauréguiberry S, Graby G, Caumes E. Efficacy of short-course intramuscular
pentamidine isethionate treatment on Old World localized cutaneous leishmaniasis
in 2 patients. Clin Infect Dis. 2006 Jun 15;42(12):1812-3. PubMed PMID: 16705598.

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10: Lightburn E, Morand JJ, Meynard JB, Kraemer P, Chaudier B, Pages F, Garnotel
E, Patte JH, Banzet S, Dampierre H, Lepage J, Morillon M, Boutin JP, Hovette P,
Chouc C. [Management of American cutaneous leishmaniasis. Outcome apropos of 326
cases treated with high-dose pentamidine isethionate]. Med Trop (Mars).
2003;63(1):35-44. French. PubMed PMID: 12891748.

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