For research use only. Not for therapeutic Use.
Pentoxifylline（Cat No.:I000055）is a methylxanthine derivative used primarily to improve blood flow in conditions like peripheral artery disease and intermittent claudication. By increasing red blood cell flexibility and reducing blood viscosity, it enhances microcirculation and oxygen delivery to tissues, easing pain and improving walking capacity. Additionally, pentoxifylline possesses anti-inflammatory and immunomodulatory effects, making it useful in various vascular and inflammatory disorders. Its therapeutic versatility has extended its application to chronic kidney disease, liver disease, and wound healing research, supporting its role in vascular health and systemic inflammatory conditions.
| Catalog Number | I000055 |
| CAS Number | 6493-05-6 |
| Synonyms | NSC 637086;Oxpentifylline |
| Molecular Formula | C13H18N4O3 |
| Purity | ≥95% |
| Target | PDE |
| Solubility | DMSO: ≥ 2.8 mg/mL |
| Storage | -20°C |
| IUPAC Name | 3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione |
| InChI | InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3 |
| InChIKey | BYPFEZZEUUWMEJ-UHFFFAOYSA-N |
| SMILES | CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C |
| Reference | </br>1:Effect of Pentoxifylline in Ameliorating Myocardial Injury in Patients With Myocardial Infarction Undergoing Thrombolytic Therapy: A Pilot Randomized Clinical Trial. Namdar H, Zohori R, Aslanabadi N, Entezari-Maleki T.J Clin Pharmacol. 2017 May 17. doi: 10.1002/jcph.926. [Epub ahead of print] PMID: 28513852 </br>2:Oral Pentoxifylline Associated with Pentavalent Antimony: A Randomized Trial for Cutaneous Leishmaniasis. Brito G, Dourado M, Guimarães LH, Meireles E, Schriefer A, de Carvalho EM, Machado PRL.Am J Trop Med Hyg. 2017 May;96(5):1155-1159. doi: 10.4269/ajtmh.16-0435. PMID: 28500815 </br>3:Administration of pentoxifylline to improve anemia of hemodialysis patients. Shahbazian H, Ghorbani A, Zafar-Mohtashami A, Balali A, AleAli A, Lashkarara GR.J Renal Inj Prev. 2016 Nov 26;6(1):61-64. doi: 10.15171/jrip.2017.11. eCollection 2017. PMID: 28487874 Free PMC Article</br>4:Repurposing Pentoxifylline for the Treatment of Fibrosis: An Overview. Wen WX, Lee SY, Siang R, Koh RY.Adv Ther. 2017 May 8. doi: 10.1007/s12325-017-0547-2. [Epub ahead of print] Review. PMID: 28484954 </br>5:Pentoxifylline and prevention of contrast-induced nephropathy: Is it efficient in patients with myocardial infarction undergoing coronary angioplasty? Eshraghi A, Naranji-Sani R, Pourzand H, Vojdanparast M, Morovatfar N, Ramezani J, Khamene-Bagheri R, Nezafati P.ARYA Atheroscler. 2016 Sep;12(5):238-242. PMID: 28458699 Free PMC Article</br>6:Pentoxifylline increase sperm motility in devitrified spermatozoa from asthenozoospermic patient without damage chromatin and DNA integrity. Nabi A, Khalili MA, Fesahat F, Talebi A, Ghasemi-Esmailabad S.Cryobiology. 2017 Apr 25. pii: S0011-2240(16)30371-6. doi: 10.1016/j.cryobiol.2017.04.008. [Epub ahead of print] PMID: 28455156 </br>7:Pentoxifylline plus ACEIs/ARBs for proteinuria and kidney function in chronic kidney disease: a meta-analysis. Liu D, Wang LN, Li HX, Huang P, Qu LB, Chen FY.J Int Med Res. 2017 Apr;45(2):383-398. doi: 10.1177/0300060516663094. Epub 2017 Jan 1. PMID: 28415944 </br>8:The effects of pentoxifylline adminstration on fracture healing in a postmenopausal osteoporotic rat model. Vashghani Farahani MM, Ahadi R, Abdollahifar M, Bayat M.Lab Anim Res. 2017 Mar;33(1):15-23. doi: 10.5625/lar.2017.33.1.15. Epub 2017 Mar 27. PMID: 28400835 Free PMC Article</br>9:Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline. Kang Y, Yan W, Fang H, Zhang G, Du Y, Wang L, Cui H, Shi G.Oxid Med Cell Longev. 2017;2017:7908072. doi: 10.1155/2017/7908072. Epub 2017 Mar 12. PMID: 28386312 Free PMC Article</br>10:Pentoxifylline Regulates Plasminogen Activator Inhibitor-1 Expression and Protein Kinase A Phosphorylation in Radiation-Induced Lung Fibrosis. Lee JG, Shim S, Kim MJ, Myung JK, Jang WS, Bae CH, Lee SJ, Kim KM, Jin YW, Lee SS, Park S.Biomed Res Int. 2017;2017:1279280. doi: 10.1155/2017/1279280. Epub 2017 Feb 27. PMID: 28337441 Free PMC Article |
