Pep19-2.5

• CAT Number: I042739
• CAS Number: 1322711-38-5
• Molecular Formula: C135H187N37O22S
• Molecular Weight: 2712.23
• Purity: ≥95%

Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis[1].
Pep19-2.5 (5 mg/kg; i.v.; single dose), combinded with Ceftriaxone (HY-B0712) (15 mg/kg; i.v.; single dose) displays synergism effect and kills bacteria and eliminates bacteremia 30 min post treatment, Pep19-2.5 also notably counteracts the endotoxin-inducing potential of ceftriaxone in sepsis model of rabbit[2].

Reference

[1]. Heinbockel L, et al. Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5. Front Immunol. 2018 Jul 26;9:1704.
 [Content Brief]

[2]. Bárcena-Varela S, et al. Coupling killing to neutralization: combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits. Exp Mol Med. 2017 Jun 16;49(6):e345.
 [Content Brief]

[3]. Jannadi H, et al. Antimicrobial peptides Pep19-2.5 and Pep19-4LF inhibit Streptococcus mutans growth and biofilm formation. Microb Pathog. 2019 Aug;133:103546.
 [Content Brief]