For research use only. Not for therapeutic Use.
PEPA (Cat No.:I001575) is a selective and potent positive allosteric modulator (PAM) of the α7 nicotinic acetylcholine receptor (nAChR), a receptor involved in cognitive processes, memory, and attention. By enhancing the activity of the α7 receptor, PEPA has been studied for its potential therapeutic effects in neurological and psychiatric disorders such as Alzheimer’s disease, schizophrenia, and cognitive dysfunction. Research suggests that PEPA can improve synaptic plasticity and neurotransmitter release, potentially offering cognitive-enhancing benefits. Further clinical studies are necessary to evaluate its safety, efficacy, and therapeutic potential for these conditions.
| Catalog Number | I001575 |
| CAS Number | 141286-78-4 |
| Synonyms | 2-(2,6-difluoro-4-((2-(phenylsulfonamido)ethyl)thio)phenoxy)acetamide |
| Molecular Formula | C16H16F2N2O4S2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | 100 mM in DMSO ; 25 mM in ethanol |
| Storage | Store at RT |
| IUPAC Name | 2-[4-[2-(benzenesulfonamido)ethylsulfanyl]-2,6-difluorophenoxy]acetamide |
| InChI | InChI=1S/C16H16F2N2O4S2/c17-13-8-11(9-14(18)16(13)24-10-15(19)21)25-7-6-20-26(22,23)12-4-2-1-3-5-12/h1-5,8-9,20H,6-7,10H2,(H2,19,21) |
| InChIKey | GTACSIONMHMRPD-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)S(=O)(=O)NCCSC2=CC(=C(C(=C2)F)OCC(=O)N)F |
| Reference | <p style=/line-height:25px/> |
