For research use only. Not for therapeutic Use.
Peptide 74 is a synthetic peptide containing the prodomain sequence of matrix metalloproteinase (MMP). Peptide 74 inhibits the activated form of the 72-kDa type IV collagenase in vitro[1].
Peptide 74 (30 μM) reduces both A2058 and HT 1080 tumor cell invasion by 60-80%[1].
Peptide 74 (30 μM) shows no cytotoxic action and does not inhibit chemotaxis or affect HT1080 and A2058 human tumor cells number[1].
| Catalog Number | M117722 |
| CAS Number | 132116-39-3 |
| Molecular Formula | C62H107N23O20S2 |
| Purity | ≥95% |
| Reference | [1]. A Melchiori, et al. Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment. Cancer Res. 1992 Apr 15;52(8):2353-6. [2]. P P Lee, et al. Functional role of matrix metalloproteinases (MMPs) in mammary epithelial cell development. J Cell Physiol. 2001 Jul;188(1):75-88. |
